Une équipe de l’Inserm vient de mettre en évidence au moins trois nouvelles molécules capables d’enrayer les infections par le cytomégalovirus humain, un virus particulièrement dangereux pour les personnes immunodéprimées et les fœtus.
Une excellente nouvelle pour les bébés à venir.
L'article en anglais c'est ici :
Cotin S, Calliste CA, Mazeron MC, Hantz S, Duroux JL, Rawlinson WD, Ploy MC, Alain S
Eight flavonoids and their potential as inhibitors of human cytomegalovirus replication. [JOURNAL ARTICLE]
Antiviral Res 2012 Sep 21.
The drugs currently available for treatment of severe human cytomegalovirus (HCMV) infections suffer from many drawbacks, particularly toxicity, and potential teratogenicity contraindicating their use in target populations such as pregnant women. The emergence of drug-resistant strains is still a problem for disease management, particularly in immunosuppressed populations where antivirals are used for extended periods of time. The flavonoid family of drugs contains promising candidates as they have low toxicity and inhibit different targets to currently available antivirals. We report here that, unlike their chalcon homologs, four flavonoids (baicalein, quercetin, quercetagetin and naringenin) inhibit various stages of HCMV replication, the most active anti-HCMV compound being baicalein and the less active and less selective being quercetagetin. These drugs could provide potential inhibitors of virus replication alone or in combination, without increased toxicity.http://www.sciencedirect.com/science/article/pii/S0166354212002070